{"id":5384,"date":"2023-08-22T10:42:08","date_gmt":"2023-08-22T14:42:08","guid":{"rendered":"https:\/\/koreatimesphila.com\/?p=5384"},"modified":"2023-08-22T10:42:12","modified_gmt":"2023-08-22T14:42:12","slug":"why-is-chemotherapy-different-for-each-patient-when-its-the-same-cancer","status":"publish","type":"post","link":"https:\/\/koreatimesphila.com\/en\/why-is-chemotherapy-different-for-each-patient-when-its-the-same-cancer\/","title":{"rendered":"\uac19\uc740 \uc554\uc778\ub370 \ud658\uc790\ub9c8\ub2e4 \ud56d\uc554 \uce58\ub8cc\uac00 \ub2e4\ub978 \uc774\uc720\ub294?"},"content":{"rendered":"

\uc720\uc804\uc790 \ubcc0\uc774 \ubc1c\ud604 \uc5ec\ubd80 \ub530\ub77c \uce58\ub8cc\uc81c \ub2ec\ub77c<\/p>\n\n\n\n

\u2018\uc554 \uc9c4\ub2e8=\uc0ac\ub9dd \uc120\uace0\u2019\uc600\ub358 \uc804\uacfc \ub2ec\ub9ac \ud56d\uc554 \uc57d\ubb3c \uce58\ub8cc\uac00 \ubc1c\uc804\ud558\uba74\uc11c \uc9c4\ud589\u00b7\uc804\uc774\uc131 \uc554 \ud658\uc790 \uc0dd\uc874\uc728\uacfc \uc0b6\uc758 \uc9c8\uc774 \ud06c\uac8c \uac1c\uc120\ub410\ub2e4. \uc554 \uce58\ub8cc\ubc95\uc740 \ud06c\uac8c \uad6d\uc18c \uce58\ub8cc\uc640 \uc804\uc2e0 \uce58\ub8cc\ub85c \ub098\ub25c\ub2e4. 1\uae30\ub97c \ud3ec\ud568\ud55c \ucd08\uae30 \uc554 \ub4f1 \ub0ae\uc740 \ubcd1\uae30 \uc554\uc774\ub77c\uba74 \uc218\uc220\uc801 \uc808\uc81c\ub97c \ud3ec\ud568\ud55c \uad6d\uc18c \uce58\ub8cc\uac00 \uc8fc\uc694 \uce58\ub8cc\ubc95\uc774\uc9c0\ub9cc, 2~3\uae30 \uc774\uc0c1\uc758 \uc9c4\ud589\uc131 \uc554 \ubc0f \uc6d0\uaca9 \uc804\uc774\ub97c \ub3d9\ubc18\ud55c \uc804\uc774\uc131 \uc554(4\uae30)\uc774\ub77c\uba74 \uc804\uc2e0 \uc57d\ubb3c \uce58\ub8cc\uac00 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc554\uc5d0 \ub300\ud55c \uc804\uc2e0 \uc57d\ubb3c \uce58\ub8cc\ub294 \ud06c\uac8c\u2018\uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\u2019\u2018\ud45c\uc801\uce58\ub8cc\uc81c\u2019\u2018\uba74\uc5ed\uce58\ub8cc\uc81c(\uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c)\u2019\ub85c \ub098\ub25c\ub2e4. \uc774\ub4e4 \uc911 \uac00\uc7a5 \uba3c\uc800 \ub4f1\uc7a5\ud55c \uc57d\ubb3c\uc740 \uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\uc778\ub370 2\ucc28 \uc138\uacc4\ub300\uc804 \ud6c4 \ub9ce\uc740 \uc885\ub958\uc758 \uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\uac00 \uac1c\ubc1c\ub410\uace0, \uc77c\ubd80 \uc57d\ubb3c\uc740 \ud604\uc7ac\uae4c\uc9c0\ub3c4 \uc554 \ud658\uc790 \uce58\ub8cc\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n\n\n\n

\uc624\ucda9\ub82c \uc911\uc559\ub300\ubcd1\uc6d0 \uc554\uc13c\ud130 \ud608\uc561\uc885\uc591\ub0b4\uacfc \uad50\uc218\ub294 \u201c\uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\ub294 \ub2e8\uc5b4 \uadf8\ub300\ub85c \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uc138\ud3ec\uc5d0 \ub3c5\uc131\uc744 \ub098\ud0c0\ub0b4\uae30\uc5d0 \uc554\uc138\ud3ec \ubfd0\ub9cc \uc544\ub2c8\ub77c \uc815\uc0c1 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc601\ud5a5\ub3c4 \ud06c\ub2e4\ub294 \ub2e8\uc810\uc774 \uc788\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

\uc624 \uad50\uc218\ub294 \u201c\uc8fc\ub85c \uace8\uc218\ub098 \uba38\ub9ac\uce74\ub77d, \uc7a5\ub0b4 \uc0c1\ud53c\uc138\ud3ec\uc640 \uac19\uc774 \ube60\ub974\uac8c \ubd84\uc5f4\ud558\ub294 \uc138\ud3ec\uc5d0 \ube44\ud2b9\uc774\uc801\uc73c\ub85c \uc791\uc6a9\ud574 \uc124\uc0ac\u00b7\uc810\ub9c9\uc5fc\u00b7\uad6c\uc5ed\u00b7\uad6c\ud1a0 \ub4f1 \uc704\uc7a5\uad00\uacc4 \uc99d\uc0c1, \ud638\uc911\uad6c \uac10\uc18c \ub4f1 \uace8\uc218 \uc5b5\uc81c, \ud0c8\ubaa8 \ub4f1\uc758 \ubd80\uc791\uc6a9\uc774 \ud754\ud788 \ub098\ud0c0\ub09c\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

DNA \uad6c\uc870\uac00 \ubc1d\ud600\uc9c0\uace0 1980~90\ub144\ub300 \uc774\ud6c4 \ubd84\uc790 \uacf5\ud559\uc774 \ud06c\uac8c \ubc1c\uc804\ud568\uc5d0 \ub530\ub77c \uc554\uc138\ud3ec \ubc1c\ud604\uc5d0 \uacb0\uc815\uc801\uc778 \uc5ed\ud560\uc744 \ud558\ub294 \ud2b9\uc815 \uc720\uc804\uc790 \ubcc0\uc774\uac00 \uaddc\uba85\ub418\uc5c8\uace0, \uc774\ub7ec\ud55c \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc554 \uce58\ub8cc\uc5d0 \uc788\uc5b4 \uc911\uc694\ud55c \ud45c\uc801\uc774 \ub418\uae30 \uc2dc\uc791\ud588\ub2e4.<\/p>\n\n\n\n

\uc9c0\ub09c \uc218\uc2ed \ub144 \ub3d9\uc548 \uc218\ub9ce\uc740 \ud45c\uc801\uce58\ub8cc\uc81c\uac00 \uac1c\ubc1c\ub418\uc5c8\uace0 \uc9c0\uae08\uae4c\uc9c0\ub3c4 \ub110\ub9ac \uc0ac\uc6a9\ub418\uace0 \uc788\ub294\ub370, \uc774 \uacc4\uc5f4\uc758 \uc57d\ubb3c\uc740 \uae30\uc874\uc758 \uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\uc640 \ube44\uad50\ud558\uc5ec \uc554\uc138\ud3ec\uc5d0 \ub300\ud55c \ubcf4\ub2e4 \ub192\uc740 \ud2b9\uc774\uc131\uc744 \uac16\uae30\uc5d0 \uc815\uc0c1 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc601\ud5a5\uc744 \ucd5c\uc18c\ud654\ud560 \uc218 \uc788\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4.<\/p>\n\n\n\n

\uc624\ucda9\ub82c \uad50\uc218\ub294 \u201c\ud45c\uc801\uce58\ub8cc\uc81c\ub294 \ud06c\uac8c \uacbd\uad6c \uc57d\uc81c\uc778 \u2018\uc18c\ubd84\uc790\uc5b5\uc81c\uc81c\u2019\uc640 \uc8fc\uc0ac\uc81c\uc778 \u2018\ub2e8\uc77c\ud074\ub860\ud56d\uccb4\u2019\ub85c \ub098\ub20c \uc218 \uc788\uc73c\uba70, \uac01 \uc554\uc885\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \uace0\uc720\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ubc0f \uc138\ubd80 \uc544\ud615\uc5d0 \ub530\ub77c \uadf8\uc5d0 \ub9de\ub294 \uc11c\ub85c \ub2e4\ub978 \uc57d\uc81c\ub4e4\uc774 \uc0ac\uc6a9\ub41c\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

2010\ub144 \uc774\ud6c4\uc5d0\ub294 \uc554\uc758 \ubc1c\uc0dd\uacfc \uc9c4\ud589\uc774 \uc778\uccb4\uc758 \uba74\uc5ed \uae30\ub2a5\uacfc \ubc00\uc811\ud55c \uc5f0\uad00\uc774 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc9c0\uae30 \uc2dc\uc791\ud588\uace0 \uc774\ub97c \uc774\uc6a9\ud55c \uba74\uc5ed \uce58\ub8cc\uac00 \ub208\ubd80\uc2e0 \ubc1c\uc804\uc744 \uc774\ub8e8\uc5c8\ub2e4.<\/p>\n\n\n\n

\ud2b9\ud788 \uba74\uc5ed \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\ub294 T-\uc138\ud3ec\uc758 \uc218\uc6a9\uccb4 \ud639\uc740 \uc554\uc138\ud3ec \ud45c\uba74 \ub2e8\ubc31\uc9c8 \ub4f1\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc774\ub978\ubc14 \u2018\uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\u2019\uac00 \uac1c\ubc1c\ub410\ub2e4. \uc774\ub7ec\ud55c \uc57d\ubb3c\uc740 \uc554\uc138\ud3ec\uac00 \uc778\uccb4\uc758 \uba74\uc5ed \uac10\uc2dc\ub97c \ud68c\ud53c\ud558\ub294 \uac83\uc744 \ub9c9\uace0, \uc554\uc138\ud3ec\uc5d0 \ub300\uc751\ud558\ub294 \uba74\uc5ed\uc138\ud3ec\uc758 \ud65c\uc131\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0a4\ub294 \uc57d\ubb3c\ub4e4\ub85c \uc9c1\uc811 \uc554\uc138\ud3ec\uc5d0 \uc791\uc6a9\ud574 \ub3c5\uc131\uc744 \ub098\ud0c0\ub0b4\ub294 \uae30\uc874\uc758 \uc57d\ubb3c\uacfc\ub294 \ub2e4\ub978 \ud2b9\uc9d5\uc744 \uac16\ub294\ub2e4.<\/p>\n\n\n\n

\uc624\ucda9\ub82c \uad50\uc218\ub294 \u201c\uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\ub294 \uc815\uc0c1 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc9c1\uc811\uc801\uc778 \ub3c5\uc131\uc744 \ub098\ud0c0\ub0b4\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0 \ubd80\uc791\uc6a9\uc774 \uc801\uace0 \uc554\uc5d0 \ub300\ud55c \uc778\uccb4\uc758 \uba74\uc5ed \uae30\ub2a5\uc744 \ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \ub9cc\ud07c \uc885\uc591\uc5d0 \ub300\ud55c \ubc18\uc751\uc774 \ub2e4\ub978 \uc57d\uc81c\uc5d0 \ube44\ud574 \uc7a5\uae30\uac04 \uc720\uc9c0\ub41c\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4\u201d\uba70 \u201c\uadf8\ub7ec\ub098 \uba74\uc5ed \uae30\ub2a5\uc774 \uacfc\ub3c4\ud558\uac8c \ud65c\uc131\ud654\ub418\uba74\uc11c \ub098\ud0c0\ub098\ub294 \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uba74\uc5ed \uad00\ub828 \ubd80\uc791\uc6a9\uc774 \uc788\uc744 \uc218 \uc788\uae30\uc5d0 \uc804\ubb38\uac00\uc758 \uc8fc\uc758 \uae4a\uc740 \ubaa8\ub2c8\ud130\ub9c1\uc774 \ud544\uc694\ud558\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

\uc9c4\ud589\uc554 \ud658\uc790 \uce58\ub8cc\uc5d0 \uc774\ub807\ub4ef \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uc57d\uc81c\ub97c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \ub9cc\ud07c \ud658\uc790 \ubcc4\ub85c \uac00\uc7a5 \ud6a8\uacfc\uc801\uc77c \uac83\uc73c\ub85c \uc608\uce21\ub418\ub294 \uc57d\uc81c \ud639\uc740 \uadf8 \uc870\ud569\uc744 \ucc3e\uc544\ub0b4 \uc120\ud0dd\ud558\ub294 \uc77c\uc740 \ub9e4\uc6b0 \uc911\uc694\ud558\ub2e4.<\/p>\n\n\n\n

\uc554 \uc885\ub958\ub098 \ud2b9\uc131, \uc9c8\ubcd1 \ubc0f \ud658\uc790 \uc0c1\ud0dc\uc5d0 \ub530\ub77c \uce58\ub8cc\ubc95\uc774 \uac1c\ubcc4\u00b7\uc138\ubd84\ud654\ub3fc\uc57c \ud558\uba70 \uc2ec\uc9c0\uc5b4 \uac19\uc740 \uc554\uc885\uc774\ub77c\uace0 \ud558\ub354\ub77c\ub3c4 \ud2b9\uc815 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774 \ubc1c\ud604 \uc5ec\ubd80 \ub4f1\uc5d0 \ub530\ub77c\uc11c \uc0ac\uc6a9\ud558\ub294 \uc57d\ubb3c\uc774 \ud06c\uac8c \ub2ec\ub77c\uc9c8 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n

\uac19\uc740 4\uae30 \uc804\uc774\uc131 \ube44\uc18c(\u975e\u5c0f)\uc138\ud3ec \ud3d0\uc554 \ud658\uc790\ub77c\uace0 \ud558\ub354\ub77c\ub3c4 \uacbd\uad6c \ud45c\uc801\uce58\ub8cc\uc81c\ub97c \ubcf5\uc6a9\ud558\ub294 \ud658\uc790\uac00 \uc788\uc744 \uc218 \uc788\uace0, \uba74\uc5ed\uce58\ub8cc\uc81c\ub97c \ud22c\uc57d\ubc1b\ub294 \ud658\uc790\ub3c4 \uc788\uc73c\uba70, \uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\uc640 \uba74\uc5ed\ud56d\uc554\uc81c\ub97c \ubcd1\uc6a9\ud558\ub294 \ud658\uc790\ub3c4 \uc788\ub2e4.<\/p>\n\n\n\n

\uc624\ucda9\ub82c \uad50\uc218\ub294 \u201c\uc804\uc774\uc131 \ube44\uc18c\uc138\ud3ec \ud3d0\uc554 \ud658\uc790 \uc911 \uc608\ub97c \ub4e4\uc5b4 EGFR \ud639\uc740 ALK \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud655\uc778\ub41c \ud658\uc790\uc758 \uacbd\uc6b0 \uac01\uac01\uc5d0 \ud574\ub2f9\ud558\ub294 \uacbd\uad6c \ud45c\uc801 \uc57d\ubb3c(\ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c)\uc744 \ubcf5\uc6a9\ud574\uc57c \ud558\uba70, EGFR \ubc0f ALK\ub97c \ud3ec\ud568\ud574 \ubcc4\ub2e4\ub978 \ud45c\uc801 \uce58\ub8cc \ub300\uc0c1 \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud655\uc778\ub418\uc9c0 \uc54a\uc740 \ud658\uc790\ub77c\uba74 \uc554\uc138\ud3ec\uc5d0 \uc788\ub294 \ub2e8\ubc31\uc9c8\uc778 \u2018PD-L1\u2019 \ubc1c\ud604\ub3c4\uc5d0 \ub530\ub77c \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c \ub2e8\ub3c5 \ud639\uc740 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc640 \uc138\ud3ec \ub3c5\uc131 \ud56d\uc554\uc81c\ub97c \ubcd1\ud569\ud574 \ud22c\uc57d\ud55c\ub2e4\u201d\uba70 \u201c\ud2b9\ud788 PD-L1 \ubc1c\ud604\ub3c4\uac00 50% \uc774\uc0c1\uc73c\ub85c \ub192\uc740 \ud658\uc790\ub294 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c \ub2e8\ub3c5 \uce58\ub8cc\ub85c\ub3c4 \uc88b\uc740 \ubc18\uc751\uc744 \uae30\ub300\ud574 \ubcfc \uc218 \uc788\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

\ub354\ubd88\uc5b4 \ube44\uc18c\uc138\ud3ec\uc131\ud3d0\uc554\uc758 \uacbd\uc6b0 KRAS\u00b7 ROS1\u00b7BRAF\u00b7MET\u00b7RET \ub4f1 \uc57d\ubb3c \uce58\ub8cc\uac00 \uac00\ub2a5\ud55c \ud45c\uc801\uc774 \uc810\ucc28 \ub298\uc5b4\ub098\uace0 \uc788\ub294 \ucd94\uc138\uc774\uae30\uc5d0 \uc804\uc774\uc554 \ud658\uc790 \uce58\ub8cc\uc5d0 \uc788\uc5b4 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774 \ubd84\uc11d\uc758 \uc911\uc694\uc131\uc774 \uc810\ucc28 \ud655\ub300\ub418\uace0 \uc788\ub2e4.<\/p>\n\n\n\n

\uc774\uc640 \uac19\uc774 \uace0\ud615\uc554\uc758 \uce58\ub8cc\uc5d0 \uc788\uc5b4 \uc720\uc804\uc790 \uc815\ubcf4 \ubd84\uc11d \uae30\uc220\uc778 \ucc28\uc138\ub300\uc5fc\uae30\uc11c\uc5f4\ubd84\uc11d(NGS) \uac80\uc0ac\uac00 \ud65c\ubc1c\ud574 \uc9c0\uba74\uc11c \ub354 \uc804\ubb38\uc801\uc774\uace0 \uac1c\ubcc4\ud654\ub41c \uc554 \uce58\ub8cc\uac00 \uac00\ub2a5\ud574\uc84c\ub2e4.<\/p>\n\n\n\n

\uc624\ucda9\ub82c \uad50\uc218\ub294 \u201c\uac19\uc740 \uc554\uc885\uc774\uba74 \ud68d\uc77c\ud654\ub41c \uc57d\ubb3c\ub85c \ub3d9\uc77c\ud558\uac8c \uce58\ub8cc\ud588\ub358 \uacfc\uac70\uc640 \ub2ec\ub9ac NGS \uac80\uc0ac \uacb0\uacfc\ub97c \ud1b5\ud574 \ud574\ub2f9 \ud658\uc790\uc758 \uc554 \uc870\uc9c1\uc5d0\uc11c \uc720\uc804\uc790 \ubcc0\uc774\ub97c \ud655\uc778\ud558\uace0 \uadf8\uc5d0 \uac78\ub9de\uc740 \uce58\ub8cc\uc81c\ub97c \ucc3e\uc544 \ud22c\uc57d\ud558\ub294 \uc77c\uc774 \ud604\uc2e4\ud654\ub418\uba74\uc11c \uc554 \ud658\uc790 \uac1c\uc778\uc5d0\uac8c \ucd5c\uc801\ud654\ub41c \ub9de\ucda4 \uce58\ub8cc\ub97c \uc81c\uacf5\ud558\ub294 \uc774\ub978\ubc14 \u2018\uc815\ubc00 \uc758\ub8cc\u2019\uac00 \uc810\ucc28 \uc2e4\ud604\ub418\uace0 \uc788\ub2e4\u201d\uace0 \ud588\ub2e4.<\/p>\n\n\n\n

\uc624 \uad50\uc218\ub294 \u201c\uc554\uc774 \uc9c4\ub2e8\ub418\uc5c8\ub354\ub77c\ub3c4 \uac1c\ubcc4 \ud658\uc790\uc5d0\uac8c \uac00\uc7a5 \uc798 \ub9de\ub294 \uc801\uc808\ud55c \uce58\ub8cc\ubc95\uc744 \uc120\ud0dd\ud558\uc5ec \uce58\ub8cc\ud574 \ub098\uac08 \uc218 \uc788\uae30\uc5d0 \ubc14\ub85c \uc808\ub9dd\ud558\uc9c0 \uc54a\uace0 \uc554 \uc804\ubb38 \uc758\ub8cc\uc9c4\uacfc \uce58\ub8cc\uc5d0 \ub300\ud558\uc5ec \uc0c1\uc758\ud558\ub294 \uac83\uc774 \ub9e4\uc6b0 \uc911\uc694\ud558\ub2e4\u201d\uace0 \uac15\uc870\ud588\ub2e4.<\/p>\n\n\n\n

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